期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 37, 期 5, 页码 1165-1169出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200636933
关键词
antigen-presenting cells; co-stimulatory molecules; immune regulation; regulatory T cells; T cells
类别
Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily, expressed in several cells and tissues including T lymphocytes, NK cells and antigen-presenting cells (APC). GITR activation, upon interaction with its ligand (GITRL), functions as a co-activating signal. GITRL is mainly expressed on APC and GITR/GITRL interaction is important for the development of immune response. This review summarizes recent results about the GITR/GITRL system, focusing on the interplay between APC, effector and regulatory T cells.
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