期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 24, 期 5, 页码 1122-1129出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msm032
关键词
Drosophila melanogaster; nucleotide polymorphism; positive selection
Nucleotide variation in populations originating from the recent range expansion of a species should reflect their adaptation to new habitats as well as their demographic history. A survey of nucleotide variation at 109 noncoding X-chromosome fragments in a European population of Drosophila melanogaster allowed identifying some candidates to have been recently affected by positive selection. Adaptive changes leave a spatial differential footprint that can be used to discriminate among candidates by extending their study to neighboring regions. Here, we surveyed variation at an similar to 190-kb region spanning a locus exhibiting a significantly skewed frequency spectrum. A stretch of similar to 12 kb with reduced variation was detected within a continuously sequenced region that included the focal fragment. Moreover, the regions flanking this stretch exhibited an excess of high-frequency derived variants. Application of maximum likelihood ratio and goodness-of-fit tests suggested that the pattern of variation detected at the studied region (at cytological bands 17C-17D) might have been shaped by a recent selective change, most probably at or around the phantom gene that encodes CYP306A1, a cytochrome P450 enzyme in the ecdysteroidogenic pathway.
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