期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 81, 期 5, 页码 679-684出版社
WILEY
DOI: 10.1038/sj.clpt.6100098
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The aim of this study was to determine the influence of amiodarone on the pharmacokinetics of simvastatin and pravastatin in humans. This was a prospective, crossover, randomized, open-label study performed in 12 healthy volunteers comparing the pharmacokinetics of a single oral dose of simvastatin ( 40 mg) or pravastatin ( 40 mg) taken alone and after 3 days of amiodarone ( 400 mg/day). Amiodarone increased simvastatin acid AUC ( area under the plasma concentration-time curve)(0-24h), peak plasma concentration ( C-max), and t(1/2) by 73% ( P = 0.02), 100% ( P = 0.02), and 48% ( P = 0.06), respectively, whereas it did not significantly alter pravastatin pharmacokinetics. Point estimates and 90% confidence intervals for simvastatin acid, simvastatin lactone, and pravastatin AUC(0-24) h were 154% ( 109-216%), 155% ( 109-227%), and 86% ( 63-118%), respectively. If amiodarone and a statin have to be simultaneously prescribed, pravastatin should be preferred to simvastatin in order to avoid a drug interaction.
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