期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 55, 期 5, 页码 752-757出版社
WILEY
DOI: 10.1111/j.1532-5415.2007.01161.x
关键词
secondary hyperparathyroidism; alendronate; vitamin D; bone mineral density; osteoporosis
OBJECTIVES: To determine whether secondary hyperparathyroidism (HPTH) due to hypovitaminosis D affects bone mineral density (BMD) response to alendronate (ALN) in elderly women with osteoporosis. DESIGN: Randomized, controlled trial with 1-year follow-up. SETTING: Two osteoporosis centers in northern Italy. PARTICIPANTS: Community-dwelling women aged 60 and older with a BMD T-score below -2.5 and secondary HPTH with vitamin D insufficiency. INTERVENTION: One hundred twenty subjects were randomly assigned to receive ALN 70 mg once a week alone or ALN 70 mg once a week plus calcitriol (1,25D3) 0.5 mu g daily. MEASUREMENTS: BMD measured using dual-energy x-ray absorptiometry at the lumbar spine (L1-L4), femoral neck, and total hip and serum levels of intact PTH at baseline and 12 months. RESULT: After 1 year, BMD of the lumbar spine, femoral neck, and total hip significantly increased from baseline in both groups (P <.001). Patients allocated to ALN plus 1,25D3 demonstrated a significantly higher increase in lumbar spine BMD than those receiving ALN alone (mean percentage +/- standard deviation 6.8 +/- 4.6 vs 3.7 +/- 3.2, P <.001). Serum levels of PTH did not change significantly at 1 year in the ALN group (mean percentage, -3.7 +/- 27.1, P=.13) but decreased significantly in the ALN plus 1,25D3 group (-32.1 +/- 22.1, P <.001). At 12 months, subjects with normalized PTH independent of therapy allocation had a greater increase in lumbar spine BMD than those with persistent HPTH (6.5 +/- 4.6% vs 3.7 +/- 3.4%, P <.001). Lumbar spine BMD changes showed a significant negative correlation with PTH at 1 year (correlation coefficient (rho) = -0.399, P <.001) and a positive correlation with PTH changes (i.e., baseline value - 1 year value; rho=0.295, P=.005). CONCLUSION: Persistence of secondary HPTH reduces BMD response to ALN in older women with osteoporosis.
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