期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 26, 期 5, 页码 1005-1009出版社
SOCIETY ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC
DOI: 10.1897/06-464R.1
关键词
amphibians; endocrine disruption; estrogen; gonadal differentiation; test system
The susceptibility of Xenopus (Silurana) tropicalis and Rana temporaria to ethynylestradiol (EE2), a potent estrogenic pharmaceutical and environmental pollutant, was investigated. Larval EE2 exposure caused female-biased sex ratios at concentrations as low as 0.06 nM, which is comparable to levels found in the environment. The susceptibility of the two frog species to EE2 was comparable. supporting the use of X. tropicalis as a model organism for research on developmental reproductive toxicity of estrogenic pollutants.
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