期刊
FRONTIERS IN BIOSCIENCE
卷 12, 期 -, 页码 4402-4408出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2397
关键词
non-B DNA structure; triplex DNA; H-DNA; cruciform DNA; structure-specific nuclease; chromosomal translocation; V(D)J recombination
Recently, multiple lines of evidences have shown that non-B DNA structures within the human genes may lead to chromosomal translocations, deletions and amplifications in cancer and other human diseases. In this review, we summarize the current literature on non-B DNA structures, and discuss their role in genomic instability and diseases.
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