期刊
OSTEOARTHRITIS AND CARTILAGE
卷 15, 期 5, 页码 587-590出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2006.12.005
关键词
osteoarthritis; cartilage; smoking
Objective: To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with tibial cartilage volume and tibiofemoral cartilage defects. Methods: Two hundred and ninety-seven healthy adult subjects were recruited from an existing cohort examining healthy aging, the Melbourne Collaborative Cohort Study (MCCS). Questionnaire data were obtained at recruitment to the MCCS in 1990-1994 and at magnetic resonance imaging to determine cartilage outcomes in 2003. Results: Tibial cartilage volume was positively associated with subjects who ever smoked as well as pack-years smoked, suggesting a dose-response. There was no association between smoking and presence of tibiofemoral cartilage defects. Conclusion: Our findings demonstrate that smoking is associated with increased tibial cartilage volume but not presence of tibiofemoral cartilage defects, providing further support for a beneficial effect on articular knee cartilage. (C) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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