期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 186, 期 1-2, 页码 86-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.03.014
关键词
PECAM-1; EAE; sPECAM-Fc; MS; cellular migration
资金
- NHLBI NIH HHS [HL046849, R01 HL046849] Funding Source: Medline
- NINDS NIH HHS [R01 NS037570-05A1, R01 NS037570, R56 NS037570, R01 NS37570-01, R01 NS037570-06] Funding Source: Medline
The homophilic cell adhesion molecule PECAM-1 is a major participant in the migration of leukocytes across endothelium. We examined the ability of a chimeric soluble PECAM-1 fused to human IgG-Fc to impair leukocyte entry through the blood-brain barrier and reduce CNS autoimmunity. sPECAM-Fc impaired migration of lymphocytes across brain endothelial monolayers and diminished the severity of EAE, an experimental model of MS, when administered at the onset of symptoms. However, in mice transgenic for sPECAM-Fc, the chronically elevated levels of sPECAM-Fc hastened onset of EAE. disease without significantly changing clinical score severity. Our data suggest that short-term treatment of diseases like MS with sPECAM-Fc has therapeutic potential. (c) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据