期刊
GENERAL HOSPITAL PSYCHIATRY
卷 29, 期 3, 页码 275-277出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.genhosppsych.2007.01.010
关键词
nocebo; placebo; adverse effects
类别
We describe an individual who experienced unusual negative effects while taking a placebo during a clinical drug trial. A 26-year-old male took 29 inert capsules, believing he was overdosing on an antidepressant. Subsequently, he experienced hypotension requiring intravenous fluids to maintain an adequate blood pressure until the true nature of the capsules was revealed. The adverse symptoms then rapidly abated. The nocebo effect (undesirable symptoms following administration of an inert substance that the patient believes to be an active drug) may have significant negative impacts on certain patients. Further research is warranted to better understand this phenomenon. (c) 2007 Elsevier Inc. All rights reserved.
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