Rank-order versus mean based statistics for neuroimaging

Traditional analysis of neuroimaging data uses parametric statistics, such as the t-test. These tests are designed to detect mean differences. In fact, even nonparametric techniques such as Statistical non-parametric Mapping (SnPM) use the mean-based t statistic to measure effect size. We note that these measures may not be particularly sensitive for detecting differences when the mean is not an accurate measure of central tendency - for example if one of the groups is experiencing a ceiling or floor effect (causing a skewed data distribution). Here we introduce a nonparametric approach for neuroimaging data analysis that is based on the rank-order of data (and is therefore less influenced by outliers than the t-test). We suggest that this approach may offer a small benefit for datasets where the assumptions of the t-test have been violated, for example datasets where data from one of the groups exhibits a skewed distribution due to floor or ceiling effects. (c) 2007 Elsevier Inc. All rights reserved.