期刊
ANDROLOGIA
卷 47, 期 9, 页码 1041-1046出版社
WILEY
DOI: 10.1111/and.12375
关键词
Assisted reproduction; fertility; in vitro; nerve growth factor; sperm motility
类别
资金
- Beijing Sciences & Technology Research & Development Project [z08050703080804]
- Chinese National Sciences & Technologies Foundation Project [2013FY110500]
- Chinese National Key Technology Support Program [2013BAI05B04]
- Chinese National Key Grant of Basic Research Project [2006CB504100]
Nerve growth factor (NGF) was first found in the central nervous system and is now well known for its multiple pivotal roles in the nervous system and immune system. However, more and more evidences showed that NGF and its receptors TrkA and p75 were also found in the head and tail of spermatozoa, which indicate the possible effect of NGF on the sperm motility. Nevertheless, the exact role of NGF in the human sperm motility remains unclear until now. In this study, we investigated the effect of NGF on human sperm motility, and the results showed that NGF could promote human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa. Further analysis demonstrated that NGF promoted the sperm motility in a dose-dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques.
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