期刊
DEVELOPMENTAL CELL
卷 12, 期 5, 页码 683-698出版社
CELL PRESS
DOI: 10.1016/j.devcel.2007.03.003
关键词
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资金
- Intramural NIH HHS [Z01 HD001501-16, Z01 HD001501-14] Funding Source: Medline
Cell fusion is fundamental for reproduction and organ formation. Fusion between most C. elegans epithelial cells is mediated by the EFF-1 fusogen. However, fusion between the anchor cell and the utse syncytium that establishes a continuous uterine-vulval tube proceeds normally in eff-1 mutants. By isolating mutants where the anchor-cell fails to fuse, we identified aff-1. AFF-1 ectopic expression results. infusion of cells that normally do not fuse in C. elegans. The fusogen activity of AFF-1 was further confirmed by its ability to fuse heterologous cells. AFF-1 and EFF-1 differ in their fusogenic activity and expression patterns but share eight conserved predicted disulfide bonds in their ectodomains, including a putative TGF-beta-type-I-Receptor domain. We found that FOS-1, the Fos transcription factor ortholog that controls anchor-cell invasion during nematode development, is a specific activator of aff-l-mediated anchor-cell fusion. Thus, FOS-1 links cell invasion and fusion in a developmental cascade.
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