期刊
NATURE NEUROSCIENCE
卷 10, 期 5, 页码 546-548出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1889
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资金
- NIMH NIH HHS [MH51106] Funding Source: Medline
Experiments in hippocampal area CA1 suggest that long-term potentiation could be associated with spine addition and enlargement, and long-term depression ( LTD) with spine shrinkage and loss. Is this a general principle of synaptic plasticity? We used two-photon microscopy to measure dendritic spines in rat cerebellar Purkinje cells. Neither local synaptic induction of LTD nor global chemical induction of LTD changed spine number or size. Conversely, a manipulation that evoked persistent dendritic spine retraction did not alter parallel fiber - evoked excitatory postsynaptic currents.
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