期刊
APOPTOSIS
卷 12, 期 5, 页码 869-876出版社
SPRINGER
DOI: 10.1007/s10495-007-0748-2
关键词
apoptosis; mitochondrial carrier proteins; mitochondrial pores; BCL-2 family members; BID; mitochondrial carrier homolog 2 (Mtch2); ADP/ATP translocase (ANT); voltage dependent anion channel (VDAC)
Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.
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