期刊
NEUROLOGICAL SCIENCES
卷 28, 期 -, 页码 S89-S93出版社
SPRINGER
DOI: 10.1007/s10072-007-0757-5
关键词
calcitonin gene-related peptide; neurogenic vasodilatation; migraine; receptor antagonist; meninges
Over the last 100 years, the discovery of new analgesics has been a complex and difficult task. However, remarkable progress in the identification of novel molecular targets relevant for pain medicines has been reported. Here we will focus on the neuropeptide calcitonin gene-related peptide (CGRP) and its receptors (CGRP-R) because of their role in migraine mechanism and migraine therapy. Recent preclinical and clinical data on the localisation, regulation and plasma levels of CGRP and on the function of CGRP-R will be summarised. The reviewed findings highlight the major function of CGRP in migraine and the use of CGRP-R antagonists as a novel approach for the treatment of migraine attack and, perhaps, as migraine prophylactic medicines.
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