期刊
EXPERIMENTAL GERONTOLOGY
卷 42, 期 5, 页码 391-395出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.11.010
关键词
aging B lymphopoieis; leukemia; hematopoiesis
资金
- NIA NIH HHS [R01 AG021450] Funding Source: Medline
The production of B lymphocytes begins to decline steadily early in adult life and is severely compromised in the elderly. This occurrence has been attributed to intrinsic defects in early hematopoietic progenitors and B cell precursors as well as to microenvironmental changes in aged bone marrow. The aim of this review is to present an overview of B lymphocyte senescence and its underlying causes and to discuss its impact on immune function and leukemogenesis in aged individuals. (C) 2006 Elsevier Inc. All rights reserved.
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