期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 10, 期 -, 页码 6021-6026出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S90382
关键词
barium chloride; colostrum; immune cells; intracellular Ca2+; immunotoxicology
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
- Fundacao de Apoio a Pesquisa de Mato Grosso (FAPEMAT), Brazil
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, CAPES, Brazil
Purpose: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this naturally occurring element is also associated with human activity and industrial pollution. The study evaluated the administration of barium nanoparticles to colostrum, assessing the viability and functional activity of colostral mononuclear phagocytes. Methods: Colostrum was collected from 24 clinically healthy women (aged 18-35 years). Cell viability, superoxide release, intracellular Ca2+ release, and phagocyte apoptosis were analyzed in the samples. Results: Treatment with barium lowered mononuclear phagocyte viability, increased superoxide release, and reduced intracellular calcium release. In addition, barium increased cell death by apoptosis. Conclusion: These data suggest that nanoparticles of barium in colostrum are toxic to cells, showing the importance of avoiding exposure to this element.
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