期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 51, 期 5, 页码 580-586出版社
WILEY
DOI: 10.1002/mnfr.200600204
关键词
cyanidin-3-O-beta-glucoside; dimethylarginine dimethylamino hydrolase-2; endothelial cells; heme oxygenase-1; nitric oxide synthase
The aim of the present research was to investigate the effect of cyanidin-3-O-beta-glucoside (C3G) on heme oxygenase-1 (HO-1), endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS) and dimethylarginine dimethylamino hydrolase-2 (DDAH-2) expression in cultured endothelial cells. Different concentrations (0.00625-250 mu M) of C3G were tested in order to investigate possible beneficial and harmful effects of C3G. Our data demonstrated that C3G increased the induction of eNOS and HO-1 in a dose-dependent manner. Higher concentration (62.5 - 250 mu M) also resulted in increase of isoprostane, cGMP and PGE(2) levels and in induction of iNOS with consequent oxidative stress. In conclusion, our data evidence that C3G may exert various protective effects against endothelial dysfunction, whereas potentially harmful effects of C3G appear to be limited to concentrations very difficult to be reached in physiological conditions unless there is abundant oral supplementation.
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