期刊
DEVELOPMENTAL DYNAMICS
卷 236, 期 5, 页码 1287-1294出版社
WILEY
DOI: 10.1002/dvdy.21074
关键词
septation; atrial septum; atrioventricular cushions; muscularization; dorsal mesocardium; spina vestibuli
资金
- NCRR NIH HHS [P20-RR016434, P20 RR016434, C06 RR015455, C06 RR018823] Funding Source: Medline
- NHLBI NIH HHS [T32 HL007260, R01 HL084285-02, R01 HL084285-01A1, R01 HL084285-04, R01 HL084285-03, T32 HL07260, R01 HL084285] Funding Source: Medline
- NICHD NIH HHS [P01 HD039946-019001, P01 HD039946-029001, P01 HD039946] Funding Source: Medline
The mesenchymal tissues involved in cardiac septation are derived from different sources. In addition to endocardial-derived mesenchyme, the heart also receives contributions from the neural crest, the proepicardium, and the dorsal mesenchymal protrusion (DMP). Whereas the contributions of the neural crest and proepicardium have been thoroughly studied, the DAIP has received little attention. Here, we present the results of a comprehensive spatiotemporal study of the DMP in cardiac development. Using the Tie2-Cre mouse, immunohistochemistry, and AMIRA reconstructions, we show that the DMP, in combination with the mesenchymal cap on the primary atrial septum, fuse with the major atrioventricular cushions to close the primary atrial foramen and to form the atrioventricular mesenchymal complex. In this complex, the DMP constitutes a discrete prominent mesenchymal component, wedged in between the major cushions. This new model for atrioventricular septation may provide novel insights into understanding the etiology of congenital cardiac malformations. Developmental Dynamics 236:1287-1294, 2007. (C) 2007 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据