期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 14, 期 5, 页码 449-451出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1225
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资金
- MRC [G0500367, G0500365] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [B20127] Funding Source: Medline
- Medical Research Council [G0500365, G0500367] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [B20127] Funding Source: researchfish
- Medical Research Council [G0500367, G0500365] Funding Source: researchfish
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
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