期刊
AUTOPHAGY
卷 3, 期 3, 页码 245-248出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.3717
关键词
Toxoplasma gondii; T cell; LC3; Beclin 1; Rab7; LAMP-1; TNF-alpha
类别
资金
- NIAID NIH HHS [AI48406] Funding Source: Medline
A fundamental question in host-pathogen interaction is to determine if the immune system activates fusion with the lysosomes to eradicate pathogens. We recently reported that this task is accomplished by the interaction between CD40 expressed on macrophages and CD154 expressed on activated CD4(+) T cells. CD40 stimulation of macrophages induces vacuole-lysosome fusion through autophagy and results in killing of the obligate intracellular pathogen Toxoplasma gondii. This response is independent of IFN-gamma, STAT1 and p47 GTPases. We now report that vacuole-lysosome fusion is dependent on synergy between TRAF6 signaling downstream of CD40 and TNF-alpha. These studies identified a new paradigm by which T cells eradicate an intracellular pathogen within macrophages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据