期刊
CLINICAL NEUROPHYSIOLOGY
卷 118, 期 5, 页码 999-1009出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2006.11.311
关键词
muscle fatigue; experimental pain; exteroceptive suppression; sustained contraction; descending inhibition
资金
- NIDCR NIH HHS [1 R01 DE015420-01] Funding Source: Medline
Objective: To investigate the effects of muscle fatigue induced by low-level isometric jaw-clenching and subsequent glutamate-evoked muscle pain on the exteroceptive suppression (ES) response and resting electromyographic (EMG) activities in human jaw muscles. Methods: The resting EMG activity and the ESs were recorded before (baseline), after low-level jaw-clenching (Post1), after subsequent glutamate or isotonic saline injections into the left masseter (Post2), and 60 min after the clenching (Post3) in 23 healthy volunteers. Results: The late ES (ES2) showed more inhibition at Post1 compared with baseline (P < 0.05). It was less inhibited after both types of injections (Post2), and increased at Post3 again (P < 0.05) with no significant difference between the glutamate and isotonic saline sessions. The resting EMG activity increased at Post1 and Post2 (P < 0.05). The glutamate injection further increased the resting EMG activity in the injected muscle (P < 0.01). Conclusions: Muscle fatigue influences inhibitory reflex pathways in jaw-closing muscles and subsequent acute muscle pain potentiates the local increase in the resting EMG activity of the painful muscle. Significance: Muscle fatigue which can be observed in patients with oral dysfunctions may interact with nociceptive regulation and influence the clinical presentation of jaw symptoms and function. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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