期刊
GENETICS
卷 176, 期 1, 页码 703-709出版社
OXFORD UNIV PRESS INC
DOI: 10.1534/genetics.106.070201
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资金
- NIGMS NIH HHS [R01 GM066228, R56 GM066228, GM066228] Funding Source: Medline
Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.
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