期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 12, 期 -, 页码 4536-4546出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2408
关键词
DNA triplex; autosomal dominant polycystic kidney disease; tuberous sclerosis complex; sickle cell disease; persistence of fetal hemoglobin; Friedreich's ataxia; lymphoma; review
资金
- NIDDK NIH HHS [DK061458] Funding Source: Medline
Mutagenesis is the fulcrum for the balance between the fidelity of the genetic code and evolution. While there are an enormous number of extrinsic factors driving mutagenesis, alternative DNA secondary structure is one of the intrinsic components that impacts regional genomic stability. Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine.polypyrimidine mirror repeat sequences.
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