期刊
NATURE MEDICINE
卷 13, 期 5, 页码 625-630出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1572
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资金
- NIAID NIH HHS [R01 AI-35678, R21 AI056101] Funding Source: Medline
- NIDDK NIH HHS [R37DK50814] Funding Source: Medline
The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) circumvents the bladder barrier by harboring in these Rab27b/ CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs). Incorporation of UPEC into BEC fusiform compartments enabled bacteria to escape elimination during voiding and to re-emerge in the urine as the bladder distended. Notably, treatment of UPEC-infected mice with a drug that increases intracellular cAMP and induces exocytosis of fusiform vesicles reduced the number of intracellular E. coli.
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