期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 11, 期 3, 页码 487-489出版社
AMER CHEMICAL SOC
DOI: 10.1021/op700025d
关键词
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Synthetic improvements in the preparation of clopidogrel are described. The synthesis was accomplished in four steps or one-pot in above 70% overall yield. The process featured PTC catalyzed alkaline hydrolysis of the key intermediate 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile and highly effective kinetic resolution of racemic clopidogrel using L-camphorsulphonic acid in toluene and has been successfully used in a 50-kg pilot test.
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