期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 12, 期 -, 页码 3177-3193出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2305
关键词
ABC transporters; lipid transport; HDL biogenesis; atherosclerosis; surfactant; retinal dystrophy; ichthyosis; review
During the past years, available evidence suggests that members of a novel family of structurally highly related multispan proteins, designated ABC Asubclass transporters, exert critical functions in the control of cellular lipid transport processes. Loss-of-function scenarios, thus far, have revealed pivotal roles of individual ABC A-transporters in specialized lipid secretory pathways of the cell including HDL biogenesis ( ABCA1), lung surfactant production ( ABCA3), retinal integrity ( ABCA4/ ABCR) and skin lipid barrier formation ( ABCA12). Although the specific transporter activities of many members of this novel protein family have not yet been established in detail, available evidence indicates that ABC A-subclass transporters function as key components of highly specialized cellular phospho- and sphingolipid export machineries in major physiologic systems.
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