期刊
MATERIALS LETTERS
卷 61, 期 13, 页码 2601-2605出版社
ELSEVIER
DOI: 10.1016/j.matlet.2006.10.006
关键词
microparticles; polylactide; collagen; microspheres; surface modification
To improve cytocompatibility of polylactide (PLA) and to obtain an injectable scaffold for tissue engineering, collagen-modified PLA (CPLA) microparticles were prepared. Poly-(alpha-methacrylic acid)-grafted PLA (PMAA-PLA) was obtained by photooxidization and UV induced polymerization. Suspension of PMAA-PLA microspheres with an average size of 172.8 +/- 3.6 nm was prepared with solvent evaporation technique. CPLA microparticles were prepared by adding collagen acetic acid solution into PMAA-PLA microsphere suspension prepared above. FUR spectrum of PMAA-PLA confirmed that PMAA had been grafted on PLA surface. Analytical results of FTIR, XPS, SEM, hematoxylin and eosin (HE) stained and zeta potential measurement showed that the CPLA microparticles obtained by modifying PMAA-PLA microspheres with collagen molecules uniformly have a microporous structure and a particle size of less than 100 mu m. The CPLA microparticles were expected to be used as an injectable scaffold for tissue regeneration. (C) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据