期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 94, 期 1-2, 页码 5-14出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2007.03.006
关键词
innexin; pannexin; gap junctions; animal membranes; intercellular flow
资金
- NIGMS NIH HHS [R01 GM077402-01, GM077402, R01 GM077402] Funding Source: Medline
There has been some controversy as to whether vertebrate pannexins are related to invertebrate innexins. Using statistical, topological and conserved sequence motif analyses, we establish that these proteins belong to a single superfamily. We also demonstrate the occurrence of large homologues with C-terminal proline-rich domains that may have arisen by gene fusion events. Phylogenctic analyses reveal the orthologous and paralogous relationships of these homologues to each other. We show that different sets of orthologous paralogues underwent sequence divergence at markedly different rates, suggesting differential pressures through evolutionary time promoting or restricting sequence divergence. We further show that the first 2 TMS-containing halves of these homologues underwent sequence divergence more slowly than the second 2 TMS-containing halves and analyze these differences. These bioinformatic analyses should serve as useful guides for future studies of structure, function and evolutionary aspects of this important superfamily. (c) 2007 Elsevier Ltd. All rights reserved.
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