期刊
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
卷 26, 期 5, 页码 976-979出版社
SOCIETY ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC
DOI: 10.1897/06-583.1
关键词
nanolitter; fullerene; zebrafish; embryo development; ecotoxicology
The present paper summarizes, to our knowledge, the first study regarding the developmental toxicity of stable buckminsterfullerene aggregates suspended in water (nC(60)) using zebrafish (Danio rerio) as a vertebrate model. Zebrafish embryo survival, hatching rate, heartbeat, and pericardial edema were noted and described within 96 h of exposure. Fullerol (a hydroxylated C-60 derivative, C-60(OH)(16-18)) at 50 mg/L did not exert toxicity to zebrafish embryos. In contrast, nC(60) at 1.5 mg/L delayed zebrafish embryo and larval development, decreased survival and hatching rates, and caused pericardial edema. Toxicity was mitigated by adding an antioxidant (glutathione), which Suggests that a free radical-induced mechanism or another form of oxidative stress played a role in developmental toxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据