期刊
MOLECULES
卷 12, 期 5, 页码 1136-1146出版社
MDPI
DOI: 10.3390/12051136
关键词
[1,2,4]triazolo[1,5-a]pyrimidines; synthesis; antitumor activities
A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, H-1-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC50 values of 12.3 mu M and 6.1 mu M against Bel-7402 and HT-1080 cell lines respectively.
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