期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 10, 期 -, 页码 7307-7317出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S93670
关键词
magnetic particles; mesenchymal stem cells; nanofibers; tissue engineering
资金
- Academy of Sciences of the Czech Republic [RVO 68378041]
- Grant Agency of Charles University [424213, 1246314, 270513, 1262414, 1228214, 545313, 648112]
- Internal Grant Agency of the Ministry of Health of the Czech Republic [NT12156]
- Czech Science Foundation [15-15697S]
- University Centre for Energy Efficient Buildings (UCEEB) [IPv6]
- Ministry of Education, Youth, and Sports of the Czech Republic [NPU I:LO1508, NPU I:LO1309]
- MULTIFUN project (European Commission 7 FP) [262943]
- MULTIFUN project (MSMT) [7E12057]
- Czech Research Infrastructures program [LM2011025]
In this study, we have developed a combined approach to accelerate the proliferation of mesenchymal stem cells (MSCs) in vitro, using a new nanofibrous scaffold made by needleless electrospinning from a mixture of poly-epsilon-caprolactone and magnetic particles. The biological characteristics of porcine MSCs were investigated while cultured in vitro on composite scaffold enriched with magnetic nanoparticles. Our data indicate that due to the synergic effect of the poly-epsilon-caprolactone nanofibers and magnetic particles, cellular adhesion and proliferation of MSCs is enhanced and osteogenic differentiation is supported. The cellular and physical attributes make this new scaffold very promising for the acceleration of efficient MSC proliferation and regeneration of hard tissues.
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