期刊
NEURON
卷 54, 期 3, 页码 417-427出版社
CELL PRESS
DOI: 10.1016/j.neuron.2007.04.013
关键词
-
资金
- NINDS NIH HHS [R01 NS046747-04, R01 NS046747-02, R01 NS046747-03, R01-NS46747, R01 NS046747-01, R01 NS046747] Funding Source: Medline
Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic binding. We report that Dscam controls cell-intrinsic aspects of dendrite guidance in all four classes of dendrite arborization (da) neurons. Loss of Dscam in single neurons causes a strong increase in self-crossing. Restriction of dendritic fields of neighboring class III neurons appeared intact in mutant neurons, suggesting that dendritic self-avoidance, but not heteroneuronal tiling, may depend on Dscam. Overexpression of the same Dscam isoforms in two da neurons with overlapping dendritic fields forced a spatial segregation of the two fields, supporting the model that dendritic branches of da neurons use isoform-specific homophilic interactions to ensure minimal overlap. Homophilic binding of the highly diverse extracellular domains of Dscam may therefore limit the use of the same core repulsion mechanism to cell-intrinsic interactions without interfering with heteroneuronal interactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据