Lewis acid character of zero-valent gold nanoclusters under aerobic conditions: Intramolecular hydroalkoxylation of alkenes

Gold nanoclusters stabilized by poly(N-vinyl-2-pyrrolidone) (Au:PVP NCs, phi = 1.3 nm) behave as Lewis acid catalyst in aqueous media under aerobic conditions, to promote the intramolecular hydroalkoxylation of unactivated alkenes. Molecular oxygen generates a reaction center having the Lewis acidic character on the surface of Au NCs in which constituent gold atoms are formally in zero-valence state.