期刊
CHEMBIOCHEM
卷 8, 期 7, 页码 775-780出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200600554
关键词
cations; DNA structures; G quadruplexes; inhibitors; phthalocyanine
Water-soluble octacationic zinc phthalocyanine (Zn Pc) was found to be a very good G-quadruplex DNA stabilizer by using UV-melting studies and DNA polymerase stop assays, and a potent telomerase inhibitor by using the telomeric repeat amplification protocol (TRAP) assay. The compound's DNA-binding properties were also studied by surface plasmon resonance (SPR). Furthermore, CD experiments demonstrated that ZnPc could induce intramolecular G-quadruplex structure transition from the antiparallel to parallel form. More importantly, ZnPc was found to induce parallel structure formation in cation-deficient conditions. The stability of the induced structure was determined with CD melting assays.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据