Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug

An expeditious, high yield and convenient synthesis of Imatinib was carried out on an aldehydic, super acid-sensitive resin, through an efficient, micro wave-assisted synthetic protocol. The high versatility of the reaction scheme may enable the straightforward preparation of libraries of potential protein kinase inhibitors endowed with large molecular diversity. (c) 2007 Elsevier Ltd. All rights reserved.