期刊
NEUROREPORT
卷 18, 期 7, 页码 719-723出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3280d9e880
关键词
hippocampus; metabotropic glutamate receptor; rat; spatial working memory; (S)-4-carboxyphenylglycine; trans-(+/-)-I-amino-(IS, 3R)cyclopentanedicarboxylic; acid
We investigated the role of hippocampal metabotropic glutamate receptors in spatial learning and memory, using an eight-arm radial maze task. (S)-4-Carboxyphenylglycine, a group I metabotropic glutamate receptor antagonist, or trans-(+/-)-1-amino-(1S,3R)cyclopentanedicarboxylic acid, a broad-spectrum metabotropic glutamate receptor agonist, was administered into the dorsal hippocampus after rats had acquired the task. Both of these agents significantly impaired radial maze performance, suggesting a functional importance of hippocampal metabotropic glutamate receptors in spatial working memory.
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