期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 13, 期 17, 页码 2496-2503出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v13.i17.2496
关键词
quantitative structure pharmacokinetic relationship; genetic function approximation; fluoroquinolones; elimination half life
AIM: To study the relationship between quantitative structure and pharmacokinetics (QSPkR) of fluoroquinolone antibacterials. METHODS: The pharmacokinetic (PK) parameters of oral fluoroquinolones were collected from the literature. These pharmacokinetic data were averaged, 19 compounds were used as the training set, and 3 served as the test set. Genetic function approximation (GFA) module of Cerius(2) software was used in QSPkR analysis. RESULTS: A small volume and large polarizability and surface area of substituents at C-7 contribute to a large area under the curve (AUC) for fluoroquinolones. Large polarlzability and small volume of substituents at N-1 contribute to a long half life elimination. CONCLUSION: QSPkR models can contribute to some fluoroquinolones antibacterials with excellent pharmacokinetic properties. (C) 2007 The WJG Press. All rights reserved.
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