期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 19, 页码 5260-5264出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0018-07.2007
关键词
endocannabinoid; striatum; synaptic plasticity; basal ganglia; dopamine; LTD
Endocannabinoid (eCB)-mediated forms of long-term synaptic plasticity occur in several brain regions, but much remains unknown about their basic properties and underlying mechanisms. Here, we present evidence that eCB-mediated long-term depression (eCB-LTD) at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation. This dual requirement for CB1 activation and presynaptic activity is a mechanism by which eCB-LTD may be made synapse specific.
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