期刊
ORGANIC LETTERS
卷 9, 期 10, 页码 1903-1906出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol070455u
关键词
-
资金
- NCI NIH HHS [P30 CA012197-30, P30 CA12197-30, P30 CA012197] Funding Source: Medline
A new photocaged nucleoside was synthesized and incorporated into DNA with the use of standard synthesis conditions. This approach enabled the disruption of specific H-bonds and allowed for the analysis of their contribution to the activity of a DNAzyme. Brief irradiation with nonphotodamaging UV light led to rapid decaging and almost quantitative restoration of DNAzyme activity. The developed strategy has the potential to find widespread application in the light-induced regulation of oligonucleotide function.
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