Efficient functionalizations of heteroatom-bridged calix[2]arene[2]triazines on the larger rim

[GRAPHICS] Heteroatom-bridged dichlorinated calix[ 2] arene[ 2] triazines, which were synthesized from the fragment coupling reactions of cyanuric chloride and various aromatic dinucleophiles, are a unique type of platform for the construction of functional macrocyclic host molecules. Utilizing a very convenient and straightforward nucleophilic displacement reaction of dichlorinated tetraoxacalix[ 2] arene[ 2] triazine by various chelating group-containing amines, a number of functionalized tetraoxacalix[ 2] arene[ 2] triazines on the larger rim were efficiently synthesized in good yields. The resulting tetraoxacalix[ 2] arene[ 2]triazines armed with two 2,2'-bi( pyridinyl) amino or two bis(2-pyridinemethyl) amino groups selectively formed 1: 1 complexes with Cu2+ ion through most probably a chelating interaction effect.