期刊
CIRCULATION RESEARCH
卷 100, 期 9, 页码 1276-1291出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000264500.11888.f0
关键词
cell cycle; inflammation; metabolism; protein; ubiquitin; ubiquitin-like proteins
资金
- NHLBI NIH HHS [R01 HL63911-04, K24 HL69840-01] Funding Source: Medline
The discovery of the ubiquitin system was awarded with the Nobel Prize in Chemistry in 2004. Labeling of intracellular proteins for degradation by a multienzymatic complex, called the proteasome, was identified as the main function of this system. Subsequently, it was discovered that the attachment of ubiquitin to proteins can modify their function without degradation. Finally, a number of other molecules were recognized to be conjugated to proteins in a manner similar to ubiquitin and were henceforth called ubiquitin-like proteins. This review provides an overview of this class of molecules and its implication for function, subcellular location, and half-life of proteins.
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