期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 156, 期 2, 页码 154-164出版社
ELSEVIER
DOI: 10.1016/j.resp.2006.08.010
关键词
airways; upper; muscles; muscles; genioglossus; sleep; obstructive apnea; magnetic resonance imaging
资金
- NHLBI NIH HHS [HL27520, HL42236, HL07713] Funding Source: Medline
- NIBIB NIH HHS [EB1780] Funding Source: Medline
To examine the regional mechanical effects of selective genioglossus muscle activation on pharyngeal airway size and function, magnetic resonance images of the pharyngeal airway were obtained in five paralyzed, anesthetized cats over a range of positive and negative pressures in an isolated, sealed upper airway. When all results across pressure levels and pharyngeal regions were analyzed, genioglossus stimulation significantly increased the cross-sectional area (CSA) of the nasopharyngeal airway. Within specific regions, stimulation tended toward significantly increasing cross-sectional airway area in the mid-nasopharynx. Despite its dilating effect, genioglossus muscle stimulation did not alter compliance in the nasopharyngeal airway, as evidenced by the similar slopes of the pressure versus cross-sectional area relationships with and without stimulation. Finally, airway shape in the mid pharynx became more circular with either increased airway pressure or genioglossus stimulation. The results indicate that selective stimulation of the genioglossus muscle dilates the nasopharynx and provide evidence that stimulation of the genioglossus alone does not alter airway compliance. (c) 2006 Elsevier B.V. All rights reserved.
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