期刊
BIOLOGICAL PSYCHIATRY
卷 61, 期 10, 页码 1208-1210出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.07.023
关键词
DISC1; haplotype; schizophrenia; SNP
资金
- Intramural NIH HHS Funding Source: Medline
- NIMH NIH HHS [MH001760] Funding Source: Medline
Background: Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and Schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ have also been associated with hippocampal structure and function, we hypothesized that variation in a DISC1 haplotype containing Ser704Cys would be significantly associated with positive symptomatology in SZ. Methods: We tested for an association between variation in a haplotype block within the DISC1 gene containing Ser704Cys and lifetime history of positive symptoms in 199 Caucasian patients with SZ. Results: We detected significant associations between a DISC1 haplotype containing Ser704Cys and Ser704Cys genotype and lifetime severity of delusions in SZ. Conclusions: These data suggest that that the effect of DISC1 genetic variation might be associated with positive symptoms in patients with SZ.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据