期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 162, 期 1-2, 页码 32-41出版社
ELSEVIER
DOI: 10.1016/j.jneumeth.2006.12.007
关键词
stereotactic neurosurgery; surgical planning; microelectrode recording; visualization; software; deep brain stimulation; monkey
资金
- NIGMS NIH HHS [T32 GM 07250, T32 GM007250] Funding Source: Medline
- NINDS NIH HHS [R01 NS047388, R01 NS037019, R01 NS 047388, R01 NS 37019] Funding Source: Medline
Methodologies for stereotactic neurosurgery and neurophysiological microelectrode recordings (MER) in non-human primate research typically rely on brain atlases that are not customized to the individual animal, and require paper records of MER data. To address these limitations, we developed a software tool (Cicerone) that enables simultaneous interactive 3D visualization of the neuroanatomy, neurophysiology, and neurostimulation data pertinent to deep brain stimulation (DBS) research studies in non-human primates. Cicerone allows for analysis of coregistered magnetic resonance images (MRI), computed tomography (CT) scans, 3D brain atlases, MER data, and DBS electrode(s) with predictions of the volume of tissue activated (VTA) as a function of the stimulation parameters. We used Cicerone to aid the implantation of DBS electrodes in two parkinsonian rhesus macaques, targeting the subthalamic nucleus in one monkey and the globus pallidus in the other. Cicerone correctly predicted the anatomical position of 79% and 73% of neurophysiologically defined MER sites in the two animals, respectively. In contrast, traditional 2D print atlases achieved 61% and 48% accuracy. Our experience suggests that Cicerone can improve anatomical targeting, enhance electrophysiological data visualization, and augment the design of stimulation experiments. (C) 2006 Elsevier B.V. All rights reserved.
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