Hybrid molecular imprinted membranes having selectivity and separation behavior to targeted indole derivatives

Molecular imprinted membrane of indole-3-ethanol (EE) was prepared by hybridization of IE imprinted polymer powder and polysulfone (PSf) membrane. The IE imprinted polymer by covalent imprinting method was synthesized with copolymerization of indole-3-ethyl methacrylate (IEMA) and divinylbenzene (DVB). The cross-linked P(IEMA-co-DVB) was ground to be powders having less than 63 p,mu m size and then hybridized within PSf membrane by using phase inversion process. The resultant imprinted powder showed binding capacities of 1.8, 7.2, 0 and 0 p,mol g(-1) for EE, indole, 8-hydroxyquinoline and pyrrole in aqueous solution, respectively, and after hybridization with the PSf membrane, the value was 46, 26, 0 and 0 mu mol g(-1). As a result, it was found that the EE imprinted powder alone showed non-selectively binding to the IE, but, the hybridized powder within the PSf membrane bound selectively the IE. Evidence was presented that hydrophobic interaction of the PSf matrix caused the selective and efficient binding. We also showed separation behavior of the hybrid membranes and discussed on the binding selectivity of the IE molecule. In view point of hybrid effect of the PSf membrane and the cross-linked imprinted powder, the results of the separation of these substrates were considered. (C) 2007 Elsevier B.V. All rights reserved.