期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 10, 页码 2785-2788出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.02.084
关键词
allenic aromatic ethers; synthesis; antitumor agent; KB cell; KBv200 cell
Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure-activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds. (c) 2007 Elsevier Ltd. All rights reserved.
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