期刊
BEHAVIOURAL BRAIN RESEARCH
卷 179, 期 2, 页码 326-330出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2007.02.030
关键词
corridor task; striatal lesions; embryonic grafts; Huntington's disease; neurotransplantation
资金
- Medical Research Council [G0500794] Funding Source: Medline
- Medical Research Council [G0500794] Funding Source: researchfish
- MRC [G0500794] Funding Source: UKRI
Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation. (c) 2007 Elsevier B.V. All rights reserved.
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