期刊
VACCINE
卷 25, 期 20, 页码 4085-4092出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.02.050
关键词
promoter; T cell response; AIDS; prevention; envelope; Gag; Pol; Nef
资金
- Intramural NIH HHS Funding Source: Medline
Needle-free delivery of a six-plasmid HIV-1 DNA vaccine encoding EnvA, EnvB, EnvC, and subtype B Gag, Pol, and Nef underwent open-label evaluation in 15 subjects; 14 completed the 0, 1, 2 month vaccination schedule. T cell responses to HIV-specific peptide pools were detected by intracellular cytokine staining of CD4(+) [13/14 (93%)] and CD8(+) [5/14 (36%)], and by ELISpot in 11/14 (79%). Ten of 14 (71%) had ELISA antibody responses to Env proteins. Compared to a four-plasmid product, Gag- and Nef-specific T cell responses were improved, while Env-specific responses were maintained. This candidate vaccine has now advanced to Phase II evaluation. Published by Elsevier Ltd.
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