期刊
SCIENCE
卷 316, 期 5827, 页码 1046-1050出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1142950
关键词
-
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 ( SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formation in unfertilized eggs. Both processes required the activity of DSAS-6 and DSAS-4, two molecules required for canonical duplication. Thus, centriole biogenesis is a template-free self-assembly process triggered and regulated by molecules that ordinarily associate with the existing centriole. The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据